Preparation of Nickel Carbonyl

[Rescue treatment of acute nickel carbonyl poisoning].

Nephrotoxicity of nickel carbonyl in rats.

Urinary excretions of protein and amino acids were measured before and after exposure of rats to inhalation of nickel carbonyl in LD40 dosage. Urinary excretion of total protein was increased by an average of 2.4-fold on the first day after exposure and remained elevated (2.0-fold and 1.9-fold) on the second and third days. Urinary excretions of 16 neutral or basic amino acids were all increase...

Inhibition of induction of benzpyrene hydroxylase by nickel carbonyl.

Exposure of rats to nickel carbonyl by inhalation (0.2 mg Ni/liter of air/15 min) or intravenous injection (2 mg Ni/100 gm) was found to inhibit the induction of benzpyrene hydroxylase in lung and liver. Phenothiazine induction and fluorometric measurements of benzpyrene hydroxylase were performed by the methods of Wattenberg and co-workers (31, 32). Benzpyrene hydroxylase activities in lungs a...

Nickel carbonyl inhibition of cortisone induction of hepatic tryptophan pyrrolase.

Administration of nickel carbonyl to rats by intravenous in jection (2 mg Ni/100 gm body weight) inhibited the induction of hepatic tryptophan pyrrolase by cortisone but not by tryptophan. Cortisone induction was impaired on the day after admin istration of nickel carbonyl. It reached a minimum at 2 days and remained diminished for 5 days. The average activity of hepatic tryptophan pyrrolase in...

Acute nickel carbonyl poisoning: a report of 179 cases.